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Coronavirus decoded: Experts explain why COVID-19 attacks particular organs and spares others

Coronavirus decoded: Experts explain why COVID-19 attacks particular organs and spares others

The author of the study noted, “We consider here diffusive processes through the protein-protein interaction (PPI) network of proteins targeted by SARS-CoV-2 as an alternative route. We found a subdiffusive regime that allows the propagation of virus perturbations through the PPI network at a significant rate.”

The study highlighted that in order for two proteins to interact with each other, diffusion is required in the early stages. “For two proteins to find each other and form an interaction complex, they need to move inside the cell in a subdiffusive way,” Estrada said.

He also noted, “By following the main subdiffusive routes across the PPI (protein-protein interaction) network, we identify proteins mainly expressed in the heart, cerebral cortex, thymus, testis, lymph node, kidney, among others of the organs reported to be affected by COVID-19. ”

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